I tried three more times as instructed - the same error message appears. I'll call next week.The exact cause for the issue on a few computers is not known, but I think the problem is likely a missing Windows DLL in Windows 10. The fact that virtual ports were working for you in Windows 11 on the same computer supports this theory. Unfortunately, this may be something that will take time for Eltima to track down.
That said, if you did a completely new Windows 10 install on this computer, make sure that you download and install all of the manufacturer's drivers for the computer and perform all of the Windows updates. One of the manufacturer drivers or Windows updates may contain a required DLL.