I have a similar issue with the through mount connection on the Mach 2 when I use USB3. Works fine until we get below a certain temp, then it breaks up.
Some cables work better than others, but I haven't been able to make it completely go away except by changing it to USB 2. I bought myself a new cold weather USB 3 hub thinking maybe that would help, but it didn't.
What works for me right now is PC->Mach2 mount->Camera->hub->other stuff. So only the camera is running USB3. If I rearrange it to PC->Mach2->Hub->Camera then it fails when temp goes below about 5F.